New Orleans Saints running back Alvin Kamara (knee, ankle) hasn't played a down of football since Week 13. In Week 12, early in the contest, he suffered a knee injury that had him pulled from the game.

If you're looking to fill a roster spot for your title-game matchup, here are a dozen possible pickups who could be difference-makers.

Vinnie Iyer is back for another season of fantasy football lineup advice, bringing his rankings and insights across all positions to help you make those tough Week 18 start 'em, sit 'em decisions based on matchups,

Week 17 got underway with a special Christmas tripleheader, and it will resume on Saturday afternoon. The Houston Texans and Los Angeles Chargers will begin Saturday's slate at 4:30 p.m. ET. Hopefully, you're reading this with enough time to make those last-minute lineup adjustments.