You either have a bad mouse or a bad MB. To isolate, try a Logitech USB mouse, and try your mouse in a few different USB ports.

Mustek is stocking mice that are designed by Microsoft to bring out the best of your Windows software. Microsoft mice are sleek, stylish, and functional – specifically designed for Windows with ...

If you are enjoying yours then great. I hated mine, the mouse would stop responding after just a few seconds (so it seemed) and it would take a few seconds to start responding again. This was annoying ...